VariantPulseEvidence monitor liveADr. A. Kassim, open settings
VariantPulseThe interpretation moved further toward pathogenicity without crossing a band boundary.
Likely pathogenic
As reported
Pathogenic
Multiple submitters, no conflicts
Synthetic record. No identifiers in this workspace correspond to a real person.
DNA-binding domain missense change with supportive functional assay data. Reported as likely pathogenic pending further submissions.
Read from ClinVar at the last evidence sync.
Evidence for TP53 c.440T>G has firmed up since the 2023 report: the consensus moved from likely pathogenic to pathogenic on the strength of 2 submissions. The clinical band is unchanged, so this is a confidence shift rather than a reversal. 2 records on file carry this variant and have not yet been reassessed.
Composed from the structured fields of the records cited on this page. Requires clinical verification before it informs any decision.
Global
Read from ClinVar, which aggregates submissions dominated by European-ancestry cohorts.
Regional
Modelled regional aggregation maintained inside this workspace.
VariantPulse analysis
Both sources place this variant in the same band, so there is no divergence to resolve. Regional cohorts agree with the global classification.
TP53 c.440T>G — the DNA is unchanged. The evidence around it is not.