CriticalClassification driftVP-R-2026-001Raised
BRCA1c.5522G>T (p.Ser1841Ile)BRCA1 interpretation crossed the actionable boundary
Open case- Evidence confidence
- Moderate2 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
MediumRegional conflictVP-R-2026-002Raised
LDLRc.1706-10G>ALDLR regional and global evidence disagree
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
MediumRegional conflictVP-R-2026-003Raised
GLRA1c.1214G>A (p.Arg405Gln)GLRA1 regional and global evidence disagree
Open case- Evidence confidence
- Moderate2 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
MediumEvidence strengthenedVP-R-2026-004Raised
TP53c.440T>G (p.Val147Gly)TP53 evidence strengthened since reporting
Open case- Evidence confidence
- Moderate2 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
MediumConsensus conflictVP-R-2026-005Raised
MSH2c.1006C>G (p.Pro336Ala)MSH2 submitters no longer agree
Open case- Evidence confidence
- Limited1 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
LowEvidence weakenedVP-R-2026-006Raised
SCN5Ac.3287A>G (p.Gln1096Arg)SCN5A evidence now favours a benign reading
Open case- Evidence confidence
- Limited1 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
VariantPulse