VariantPulseEvidence monitor liveADr. A. Kassim, open settings
VariantPulseHereditary cancer panel
p.His3010Asn · Hereditary breast and ovarian cancer
Current evidence agrees with the interpretation on record.
Uncertain significance
As reported
Uncertain significance
Single submitter
Current evidence for BRCA2 c.9028C>A agrees with the uncertain significance interpretation issued in 2023. The classification was last evaluated on 7 Oct 2022 and carries a single submission.
Composed from the structured fields of the records cited on this page. Requires clinical verification before it informs any decision.
Each source is shown as it reports itself. VariantPulse does not merge them into a single verdict.
| Source | Classification | Review level | Last updated | Strength | |
|---|---|---|---|---|---|
| ClinVar1 submission on record. | Uncertain significance | Single submitter | 7 Oct 2022 | Limited1 of 4 review criteria met | VCV004919695 |
| Population frequencyHighest reported allele frequency carried on the source record. | Not reported | No frequency data | 7 Oct 2022 | Reference observation | |
| LiteraturePublications linked to this variant record. | 1 indexed publication | PubMed index | Latest 2015 | Supporting context | |
| Regional Evidence IndexModelled regional aggregation maintained inside this workspace | No regional record | Not held | — | — | |
| This institutionThe interpretation issued to the patient at the time of testing. | Uncertain significance | Internal report | 8 Nov 2023 | On record |
Cited publications
BRCA2 c.9028C>A — the DNA is unchanged. The evidence around it is not.
Historical findings in the connected record system that reference this variant.
| Record | Age band | Test date | As reported | Current | Department | Clinical owner | Last contact | Review state | |
|---|---|---|---|---|---|---|---|---|---|
| VP-10958 | 25-34 | 8 Nov 2023 | VUS | VUS | Clinical Genetics | Dr. L. Haddad | Reviewed | ||
| VP-11002 | 35-44 | 12 Dec 2023 | VUS | VUS | Breast Surgery | Dr. N. Farouk | Reviewed | ||
| VP-11076 | 45-54 | 23 Jan 2024 | VUS | VUS | Oncology | Dr. R. Okonjo | Reviewed | ||
| VP-11125 | 55-64 | 29 Feb 2024 | VUS | VUS | Clinical Genetics | Dr. M. Suleiman | Reviewed |
No action required. Current evidence agrees with the interpretation on record.
Decision support only. Final interpretation remains with the qualified clinical team.