VariantPulseEvidence monitor liveADr. A. Kassim, open settings
VariantPulseHereditary cancer panel
p.Trp538Gly · Lynch syndrome
Current evidence agrees with the interpretation on record.
Uncertain significance
As reported
Uncertain significance
Reviewed by expert panel
Current evidence for MLH1 c.1612T>G agrees with the uncertain significance interpretation issued in 2023. The classification was last evaluated on 19 Dec 2018 and carries a single submission.
Composed from the structured fields of the records cited on this page. Requires clinical verification before it informs any decision.
Each source is shown as it reports itself. VariantPulse does not merge them into a single verdict.
| Source | Classification | Review level | Last updated | Strength | |
|---|---|---|---|---|---|
| ClinVar1 submission on record. | Uncertain significance | Reviewed by expert panel | 19 Dec 2018 | Strong3 of 4 review criteria met | VCV000633500 |
| Population frequencyHighest reported allele frequency carried on the source record. | Not reported | No frequency data | 19 Dec 2018 | Reference observation | |
| LiteraturePublications linked to this variant record. | 8 indexed publications | PubMed index | Latest 2021 | Supporting context | |
| Regional Evidence IndexModelled regional aggregation maintained inside this workspace | No regional record | Not held | — | — | |
| This institutionThe interpretation issued to the patient at the time of testing. | Uncertain significance | Internal report | 17 Jan 2023 | On record |
Cited publications
MLH1 c.1612T>G — the DNA is unchanged. The evidence around it is not.
Historical findings in the connected record system that reference this variant.
No action required. Current evidence agrees with the interpretation on record.
Decision support only. Final interpretation remains with the qualified clinical team.