VariantPulseEvidence monitor liveADr. A. Kassim, open settings
VariantPulseSubmitters no longer agree on how this variant should be classified.
Uncertain significance
As reported
Conflicting classifications
Conflicting submissions
Submitters no longer agree on MSH2 c.1006C>G. The 2023 report recorded uncertain significance, and current submissions are split rather than resolving to a single classification. A conflicting record is not the same as a benign one, and it is not the same as a pathogenic one. One record on file carries this variant and has not yet been reassessed.
Composed from the structured fields of the records cited on this page. Requires clinical verification before it informs any decision.
Each source is shown as it reports itself. VariantPulse does not merge them into a single verdict.
| Source | Classification | Review level | Last updated | Strength | |
|---|---|---|---|---|---|
| ClinVar2 submissions on record. | Conflicting classifications | Conflicting submissions | 4 Nov 2025 | Limited1 of 4 review criteria met | VCV004532893 |
| Population frequencyHighest reported allele frequency carried on the source record. | Not reported | No frequency data | 4 Nov 2025 | Reference observation | |
| LiteraturePublications linked to this variant record. | 4 indexed publications | PubMed index | Latest 2022 | Supporting context | |
| Regional Evidence IndexModelled regional aggregation maintained inside this workspace | Uncertain significance | 4 regional observations | 9 Jan 2026 | Cohort 5,400 | |
| This institutionThe interpretation issued to the patient at the time of testing. | Uncertain significance | Internal report | 21 Feb 2023 | On record |
Cited publications
Global
Read from ClinVar, which aggregates submissions dominated by European-ancestry cohorts.
Regional
Modelled regional aggregation maintained inside this workspace.
VariantPulse analysis
Both sources place this variant in the same band, so there is no divergence to resolve. Regional observations remain uncertain. This does not resolve the disagreement among global submitters, but it does not add to it either.
MSH2 c.1006C>G — the DNA is unchanged. The evidence around it is not.
A triage signal for the queue. Not a clinical risk score, and not a statement about any individual.
Historical findings in the connected record system that reference this variant.
| Record | Age band | Test date | As reported | Current | Department | Clinical owner | Last contact | Review state | |
|---|---|---|---|---|---|---|---|---|---|
| VP-11188 | 55-64 | 21 Feb 2023 | VUS | Conflicting | Gastroenterology | Dr. M. Suleiman | Not reviewed |